Journal «Angiology and Vascular Surgery» • 

1998 • VOLUME 4 • №1

EFFECT OF ALLICOR, A COMPOUND FROM GARLIC, ON BLOOD COAGULATION IN NORMAL SUBJECTS AND PATIENTS WITH ATHEROSCLEROTIC ARTERIAL LESIONS

Ye.M. Pivovarova, S.N. Ozhegin, E.V. Kolganova, E.N. Shakhova, G.P. Shchelchkova, V.G. Rudneva, O.G. Gryaznov, D.F. Beloyartsev
A.V. Vishnevsky Institute of Surgery, Russian Academy of Medical Sciences, Medical Centre under Administrative Department of President of the Russian Federation,
Moscow, Russia

Disorders of the plasmatic and platelet component ofhemostasis is the mein pathogenetic factor of "vascular disasters" – strokes, infarctions, thromboses. They increase the risk of postoperative complications in patients with atherosclerotic arterial lesions. A study was made of the effect ofallicor on the blood coagulation system in atherosclerotic patients and normal volunteers given the drug in a single dose or for a long time. Administration of allicor in a dose of 600 mg (one tablet 2 times a day) for 28 days brought about a decrease in platelet aggregation and lessened fibrino-gen content in normal volunteers. After a single intake ofallicor in a dose of 300 mg (one tablet) the patients with grade I-II hypercoagulation showed desaggregation andflbrinolytic effects. Platelet activity and the time offibrinolysis changed 2 hours folio wing allicor intake in a dose of 300 mg (one tablet). The antiaggregation andflbrinolytic action lasted 8-12 hours,the recovery of the previous parameters took place between 12 and 24 hours after a single drug intake.

P. 43-53

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