Journal «Angiology and Vascular Surgery» • 

1999 • VOLUME 5 • №3

THE ROLE OF CELL ADHESION MOLECULES AND CYTOKINES IN REGULATION OF INTERCELLULAR INTERACTION IN ATHEROSCLEROTIC DISEASE

A.I. Teplyakov, N.G. Kruchinsky, E.V. Prishepova, T.I. Chegerova, D.V. Teplyakova
Laboratory of Hematology and Intercellular Interaction Belorussian Scientific Research Institute of Ecological and Professional Pathology,
Mogilev, Republic of Belarus

Mechanisms of intercellular communication disturbances during atherogenesis were investigated in 29 patients with atherosclerotic lesions of major arteries (verified by echocardiography and Doppler ultrasound) including 10 complicated cases (4 patients with progressive angina pectoris and 6 – with acute cerebrovascular disorders). Cytokine (IL-la, IL-lb, IL-6, IL-8, IL-10, endothelin-1) and soluble intercellular adhesion molecules (P-, E-selectin, ICAM-1, VCAM-1) baseline levels and concentration changes during blood coagulation and standard high-shear stress were determined. Atherosclerotic lesions of vascular wall were shown to correlate with increased levels of all intercellular adhesion molecules and inflammatory cytokines (IL-lb, IL-6). Distinct elevation of all cytokines and bi-directional concentration changes of intercellular adhesion molecules in both tests was demonstrated. Soluble intercellular adhesion molecules were proposed to play a pathophysiological role in downregulation of cytokines secretion. Thus, proposed interdisciplinary approach appeared to be an adequate instrument for investigation of molecular and cell mechanisms of atherogenesis and worth further development.

KEY WORDS: Atherosclerotic, cell adhesion molecules, cytokines.

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