MODERN VIEWS OF DIABETIC ANGIOPATHY OF THE LOWER LIMBS (EPIDEMIOLOGY, RISK FACTOR, ETIOPATHOGENESIS, ATHEROSCLEROSIS OF DIABETES MELLITUS). PART I

R.Z. Losev, A.N. Koulikova
Saratov State Medical University,
Saratov, Russia

Today diabetes mellitus is one of the most important problems of modern medicine. This review provides an analysis of the reported data on the problem of vascular lesion in patients with diabetes mellitus. The authors consider the problems of diabetes mellitus epidemiology and the incidence of vascular pathology in patients with disorders of carbohydrate metabolism. Expound the characteristics of the main etiopathogenetic aspects of the origination of diabetic angiopathies with regard to the latest studies into the given subject matter. Special attention is focused on the development of atherosclerotic lesion of lower limb arteries in the presence of diabetes mellitus. The authors review the most important causes of initiation and activation of the process of vessel wall lesion and formation of atherosclerotic plaques in diabetic patients. The study of risk factors of vascular pathology with delineation of the most substantial ones is of paramount importance for both prevention and sound pathogenetic treatment of the given pathology as well as for refinement of the results of surgical treatment of atherosclerotic occlusions associated with diabetes mellitus.

KEY WORDS: diabetes mellitus, atherosclerosis, angiopathies, lower limbs.

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