Journal «Angiology and Vascular Surgery» • 

2006 • VOLUME 12 • №4

SIROLIMUS – ELUTING – STENTS (THE RESULTS OF THE FIVE-YEAR USE FOR THE TREATMENT OF CORONARY ARTERY DISEASE)

A.L. Krylov
State Establishment Research Institute of Cardiology, Tomsk Scientific Center, Siberian Branch, RAMS,
Tomsk, Russia

This paper discusses the results of the five-year clinical trials of sirolimus-eluting stents in the treatment of coronary artery disease. Analyzes outcomes of revascularization of the coronary arteries in patients with single focal lesions of the coronal arteries, multi-vessel coronary stenoses, chronic occlusion of the coronary arteries, bifurcation stenoses, and diabetes mellitus. Reviews the results of the use of sirolimus-eluting stents for the treatment of in-stent restenoses. Discusses the mechanism of antiproliferative action of rapamycin.

KEY WORDS: coronary artery disease, stents, sirolimus, rapamycin.

P. 71-82

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