Journal «Angiology and Vascular Surgery» • 

2008 • VOLUME 14 • №4

COMBINATION OF RECONSTRUCTIVE VASCULAR OPERATIONS WITH GENE-ENGINEERING TECHNOLOGIES OF ANGIOGENESIS STIMULATION: A PRESENT-DAY POLICY AIMED AT IMPROVING THE REMOTE RESULTS OF TREATING PATIENTS WITH LOWER LIMB CHRONIC ISCHAEMIA

Gavrilenko A.V., Voronov D.A., Konstantinov B.A., Bochkov N.P.
Department of Vascular Surgery, B.V. Petrovsky Russian Research Centre of Surgery, Russian Academy of Medical Sciences,
Moscow, Russia

The authors have studied therapeutic outcomes in a total of 38 patients diagnosed with occlusions of the femoropopliteal segment. In the Study Group patients (n=19), the operation of femoropopliteal bypass grafting was supplemented by using gene stimulators of angiogenesis (gene constructions with the genes of vascular endothelial growth factor, and angiogenin). The Control Group patients (n=19) were subjected to a reconstructive vascular operation alone. The remote results were followed up from six to twenty-six months, having shown reliably better therapeutic outcomes obtained in the Study Group patients, as judged by the distance of pain-free walking, the time of restoration of the baseline parameters of blood flow during the treadmill test, muscular perfusion, and the quality of life indices. A conclusion was made that the use of angiogenesis-stimulating methods combined with reconstructive vascular operations improves the long-term outcomes in patients presenting with lower limb chronic ischaemia.

KEY WORDS: lower limb chronic ischaemia, surgical management, angiogenesis, vascular endothelial growth factor, angiogenin.

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