ASSESSMENT OF THE LEVEL OF HOMOCYSTEINE AND THE STATE OF HAEMOSTASIS IN PATIENTS WITH AND WITHOUT TYPE 2 DIABETES MELLITUS IN REMOTE TERMS AFTER RECONSTRUCTIVE OPERATIONS ON THE AORTO-ILIAC SEGMENT

Pokrovsky A.V., Doguzhieva R.M., Demidova V.S., Titova M.L, Egorova V.V., Lebedeva A.N., Emeliyanov D.R.
Department of Vascular Surgery A.V. Vishnevsky Institute of Surgery under the RFA on High-Technology Medical Care,
Moscow, Russia

The authors carried out a comparative analysis of the level of homocysteine and the state of haemostasis in patients with and without type 2 diabetes mellitus in the remote terms after endured reconstructive operations on the aorto-iliac segment.

They examined a total of eighty-eight patients who had endured reconstructive operations on the aorto-iliac segment at various terms. Of these, forty-two patients were found to have a severe course of type 2 diabetes mellitus (59.9% with decompensation) and forty-six subjects without diabetes constituted the group of comparison. The average age of the patients amounted to 61.9±1.25 years, with all being smokers. The following parameters were assessed: patency of the bypasses and major arteries of the lower limbs, homocysteine, fibrinolytic activity, fibrinogen, activated partial thromboplastin time, factor XIII, thrombin time, prothrombin index, activity of antithrombin III, platelet aggregation with ADP, and glycosylated haemoglobin.

KEY WORDS: homocysteine, fibrinogen, antithrombin III, platelet aggregation thromboplastin, thrombos, occlusion.

P. 43-47

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