Comparative assessment of antiaggregant efficacy of acetylsalicylic acid and clopidogrel in peripheral atherosclerosis

Kuznetsov M.R.¹, Sergeeva N.A.², Koshkin V.M.², Boldin B.V.¹, Rodionov S.V.¹, Virganskii A.O.², Kosykh I.V.¹, Lisenkov O.P.¹, Kuznetsova V.F.¹

1) Chair of Faculty Surgery No2 of the Therapeutic Faculty of the Russian National Research Medical University named after N.I. Pirogov,
2) Chair of Faculty Surgery No1 of the Therapeutic Faculty of the Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia

Presented in the article are the results of studying antiaggregate activity of acetylsalicylic acid and clopidogrel in a total of 36 patients suffering from various-severity chronic arterial insufficiency of lower limbs on the background of atherosclerosis obliterans. The study was conducted prior to treatment for correct selection of a particular antiplatelet agent. The obtained results showed that clopidogrel was not always more efficient than acetylsalicylic acid, since there is individual sensitivity of each patients to a particular antiplatelet agent. Therefore, an individual approach is necessary to conservative therapy of arterial insufficiency of lower limbs. For some patients it is preferable to administer clopidogrel, for others – acetylsalicylic acid. In a series of cases combined treatment is justified, while some patients having low sensitivity to both acetylsalicylic acid and clopidogrel require careful selection of alternative agents influencing other thrombocyte receptors.

KEY WORDS: peripheral atherosclerosis, chronic arterial insufficiency of the lower limbs, reconstructive vascular operations, thromboelastogram, antiplatelet therapy, acetylsalicylic acid, clopidogrel.

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