Endogenous venous thrombolysis

Porembskaya O.Ya.1, Khmelniker S.M.², Shaidakov E.V.¹

1) Centre for Diagnosis and Treatment of Venous Diseases, Clinic of Scientific Research Institute of Experimental Medicine, North-West Branch of the RAMS, St. Petersburg, Russia
2) Municipal Clinical Hospital No40, Ekaterinburg, Russia

Widely incorporated into vascular surgery pharmacological thrombolysis in treatment for deep vain thrombosis is fraught with a series of unsolved problems requiring further consideration. In spite of aggressive nature of treatment in a series of cases pharmacological thrombolysis sometimes turns out ineffective. Along with it, the results of experimental studies suggest a possibility of accelerating resorption of thrombotic masses and inhibiting remodelling of the venous wall by means of influencing effector cells of endogenous thrombolysis. A detailed study of the mechanisms of thrombolysis would make it possible to formulate strict criteria for carrying out pharmacological thrombolysis and to increase its efficacy.

KEY WORDS: endogenous venous thrombolysis, thrombolysis effector cells, plasminogen activator, thrombolytic enzymes.

P. 89

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