Journal «Angiology and Vascular Surgery» • 

1997 • VOLUME 3 • №1

THE FIRST EXPERIENCE WITH THE USE OF L99TTI-DIETHYLDITHIOCARBAMATE FOR VISUALIZATION OF CEREBRAL AND MYOCARDIAL PERFUSION

Yu.B. Lishmanov, I.A. Dygai, V.S. Skuridin, N.G. Krivonogov, I.Yu. Shvera, V.I. Chernov, Zh.V. Vesnina
Laboratory of Radionuclide Research Methods, Research Institute of Cardiology, Tomsk Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences, Research Institute of Nuclear Physics, Tomsk Polytechnical University,
Tomsk, Russia

The purpose of the study was to evaluate a possibility of the use of 199TI-diethyldithiocarbamate (199TI-DDC) for cerebral and myocardial perfusion visualisation in patients with combined cerebrovascular disease (CVD) and coronary artery disease (CAD). Experimental investigations of the pharmacokinetics of 199TI-DDC have shown a possibility of using this radiopharmaceutical for cerebral and myocardial perfusion imaging. The uptake of 199TI-DDC by the brain and myocardium was 5-7% and 2.5-3% of the injected dose, respectively. All patients except for controls demonstrated cerebral hypoperfusion zones (HZ) corresponding to the regions of the affected artery. The minimal accumulation of the radiopharmaceutical was found in patients with over 75% stenoses of the internal carotid artery. Comparison of the 199TI-DDC and 199TI myocardial imaging data showed the identity of HZ in all patients. The size of the myocardial HZ on the use of 199TI-DDC was less than that on the use of 199TI Clin 5 from 12 patients. 199TI-DDC showed no redistribution phenomenon. We cannot therefore to distinguish stable and transient perfusion defects. 199TI -DDC can thus be used as an agent for simultaneous cerebral and myocardial perfusion visualization.

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