Journal «Angiology and Vascular Surgery» • 

2004 • VOLUME 10 • №2

ENDOTHELIAL VASCULAR GRAFTS (EXPERIMENTAL RESEARCH)

V.M. Sedov, D.Yu. Andreev, E.G. Semenova, L.V. Kukhareva, G.P. Pinaev, I.M. Sokolova, V.E. Dyakov
Chair of Therapeutic Surgery, Academician I.P. Pavlov State Medical University, Institute of Cytology, Russian Academy of Medical Sciences, State Electrotechnical University, Research and Production Enterprise "Ecoflon",
St. Petersburg, Russia

The authors present herein their findings obtained in bench-test and experimental studies, which made it possible to work out an original technology of creating an endothelial covering of the inner surface of vascular grafts made of polytetrafluorethylene. The new technology includes the definite sequential processes which are as follows: 1) creation of vascular endotheliocytes; 2) stimulation of growth and reproduction of endotheliocytes; 3) preparation of the graft, including creation of stable positive potential on its inner surface in order to create optimal conditions for endothelization; 4) graft endothelization itself. In order to assess efficacy of endothelial vascular grafts, we carried out a total of 105 experiments on dogs. The experimental conditions made it possible to comparatively study the standard and endothelialized grafts using them in the position of the aortic abdominal portion, carotid and femoral arteries. The new grafts turned out to possess satisfactory performance properties, which precluded formation of thromboses and hyperplasia of the noeintima, simultaneously providing good implantability.

KEY WORDS: vascular grafts, endothelialization.

P. 111-117

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