Journal «Angiology and Vascular Surgery» • 

2004 • VOLUME 10 • №4

HEMODYNAMIC EFFECTS OF CONTRAST SUBSTANCES AS DEPENDENT ON THEIR VISCOSITY AND OSMOLALITY

V.I. Amosov, N.L. Shimanovsky
I.P. Pavlov Sankt-Peterburg State Medical University,
RF Ministry of Public Health, Russian State Medical University,
RF Ministry of Public Health,
Sankt-Peterburg, Russia

This paper analyzes the current information on the role of viscosity and osmolality of the solutions of iodine-containing contrast substances used in angiology, in microcirculatory disorders due to angiography. Provides the data that confirm blood flow deceleration and the development of hypoxia during the use of more viscous dimeric substances. It is concluded that the change in microcirculation is an important indicator of the safety of modern iodine-containing contrast-diagnostic agents, among which the monomeric non-ionic substances possess an optimal combination of the high contrast and low osmolality.

KEY WORDS: microcirculation, monomeric and dimeric contrast agents.

P. 47

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