Journal «Angiology and Vascular Surgery» • 

2007 • VOLUME 13 • №1

THE EFFICACY OF CELL THERAPY IN THE TREATMENT OF PATIENTS WITH TROPHIC VENOUS ULCERS OF THE LOWER LIMBS

V.M. Sedov, D.Yu. Andreev, T.D. Smirnova, B.A. Paramonov, T.N. Enkina, A.A. Sominina, O.I. Kiselev, Yu.Yu. Suissi, L.V. Lebedev
Chair of Facuity Surgery, I.P. Pavlov Sankt-Peterburg State Medical university,
Research Institute of Influenza, Russian Academy of Medical Sciences,
Chair of Plastic and Esthetic Surgery, Sankt-Peterburg Medical Academy for Advanced Training,
CMSU No.122, Center of Ultrasound Diagnosis of Vascular Diseases,
Sankt-Peterburg, Russia

This paper analyzes the results of cell therapy carried out during multimodality treatment of 23 patients with trophic ulcers of the lower limbs because of varicosity and postthrombotic disease. Twenty-five patients were entered into the control group provided the modern wound dressings Suprasorb. It has been demonstrated that cell therapy applying fibroblasts, strain 11 00/14, noticeably upgrades the treatment efficacy. Ulcer healing was attained in all the patients of the basic group. The times of epithelialization averaged 1.5 week for varicose and 3.2 weeks for postthrombotic ulcers. In the control group, the healing of varicose trophic ulcers was recorded in 86% and of postthrombotic ulcers in 78% of patients. The times of healing averaged 3.6 and 3.9 months respectively, Cell therapy as part of multimodality treatment of trophic venous ulcers excels the modern wound dressings as regards the efficacy.

KEY WORDS: trophic venous ulcers, lower limbs, cell therapy, fibro-blast culture, healing.

P. 65-75

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