Journal «Angiology and Vascular Surgery» •
2009 • VOLUME 15 • №3
Cardioprotective effect of remote ischemic preconditioning
Maslov L.N., Lishmanov Yu.B.
Scientific-Research Institute of Cardiology of Tomsk Scientific Center of Siberian Branch of RAMS, Tomsk, Russia
Authors of review analyze papers published in 1993-2008 on problem of remote ischemic preconditioning of the heart. The main manifestations of preconditioning at a distance are a decrease in infarct size, an improvement of cardiac contractility in reperfusion period, an enhancement of cardiac tolerance to arrhythmogenic impact of ischemia-reperfusion. The published data demonstrate that the humoral factors (endogenous opioids, bradykinin, calcitonin gene-related peptide, endogenous cannabinoids) play the main role in preconditioning at a distance. In the review, it is presented data that protein kinase С, mitochondrial ATP-sensitive K+-channel, mitochondrial permeability transition pore, NO-synthase, reactive oxygen species are involved in signaling cascade of remote preconditioning.
KEY WORDS: heart, preconditioning at a distance, humoral factors, receptors, signaling cascade.
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