Hypoxic preconditioning as novel approach to prophylaxis of ischemic and reperfusion damage of brain and heart

Maslov L.N., Lishmanov Yu.B., Emelianova T.V., Prut D.A., Kolar F., Portnichenko A.G., Podoksenov Y.K., Khaliulin I.G., Wang H., Pei J.-M.
Scientific Research Institute of Cardiology of SB of RAMS, Tomsk, Russia;
Tomsk State Pedagogical University, Tomsk, Russia;
Institute of Physiology, Academy of Sciences of the Czech Republic,
Prague, Czech Republic;
Institute of Physiology NAS of Ukraine, Kiev, Ukraine,;
University of Bristol, Bristol, Great Britain;
Liaoning Medical College, Jinzhou city, Liaoning Province, China;
Fourth Military Medical University, Xi'an, Shaanxi Province, China.

Analysis of published data indicates that delayed hypoxic preconditioning essentially increases a cardiac and brain tolerance to ischemia-reperfusion. There are no experimental data in the literature on the neuroprotective effect of early hypoxic preconditioning in vivo. Clinical observations indicated that early hypoxic preconditioning exerts cardioprotective and neuroprotective effects. The single works testify that cardioprotective effect of delayed hypoxic preconditioning depend on the activation of inducible NO-synthase, KATP-channels and KCa-channels. Neuroprotective effect of hypoxic preconditioning is a consequence: erythropoietin receptor stimulation and an elevation of activity of PI3-Akt and ERK1/2 kinases. The supposed end effector of brain hypoxic preconditioning is MPT-pore.

KEY WORDS: hypoxic preconditioning, ischemia, reperfusion, heart, brain.

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