Metabolic and genetic predictors of restenosis and thrombosis of arterial bioprostheses in the femoropopliteal position

Burkov N.N., Burkova T.V., Veremeev A.V., Kudryavtseva Yu.A., Zhuravleva I.Yu.

Research Institute for Integrated Problems of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russia

The present study was aimed at analysing the role of certain cytokines in the development of restenosis and thrombosis of biological prostheses “KemAngioprosthesis”, as well as assessing the effect of polymorphic variants of genes on expression of pro- and anti-inflammatory interleukins.

Group One (n=52) was composed of patients with an unfavourable outcome (prosthesis restenosis, accompanied by thrombosis in 35 patients). Group Two (n=59) comprised patients with functioning and unaltered prostheses.

Group One patients were found to have a significantly higher level of the marker of chronic inflammation IgG and IL-8, amounting respectively to 22.43±0.75 mg/ml and to 6.34±1.008 pg/ml and 16.35±0.84 mg/ml (p=0.01) and 3.96±0.399 pg/ml (p=0.01) in Group Two patients. Analysing the effect of polymorphic variants of genes on expression of pro- and anti-inflammatory interleukins showed that polymorphism of genes of proinflammatory cytokines (TNFα, IL-8 and IL-6) is high producing and polymorphism of the gene of anti-inflammatory cytokine IL-10 is low producing. Besides, we noted a clear-cut tendency toward higher incidence of polymorphic alleles of genes of proinflammatory cytokines in Group One patients.

KEY WORDS: restenosis of anastomoses zones, biological prostheses "KemAngioprosthesis", predictors.

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