Journal «Angiology and Vascular Surgery» • 

2016 • VOLUME 22 • №4

Efficacy of intramuscular administration of stem/progenitor cells in experiment on the model of lower limb ischaemia

Poveshchenko O.V., Lykov A.P., Bondarenko N.A., Kim I.I., Yankaite E.V., Kazakov O.V., Surovtseva M.A., Bgatova N.P., Karpenko A.A., Pokushalov E.A., Konenkov V.I.

Laboratory of Cell Technologies, Scientific Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

An experimental model of lower limb ischaemia induced by ligation of the femoral artery in CBA-line mail rats was used to study efficacy and effect of intramuscular administration of autologous bone-marrow stem/progenitor cells on the process of angiogenesis. Based on the findings of laser Doppler flowmetry it was shown that administration of autologous stem/progenitor cells promotes acceleration of the processes of neoangiogenesis, which was confirmed by the results of histological study.

KEY WORDS: lower limb ischaemia, cellular therapy, autologous stem/progenitor cells, experimental model, laser Doppler flowmetry.

P. 54

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