Journal «Angiology and Vascular Surgery» • 

2017 • VOLUME 23 • №1

Calcification of atherosclerotic plaques and assessment of their stability

Ignatiev I.M.1, Chelyshev Yu.A.2, Zanochkin A.V.1, Gafurov M.R.3, Orlinskiy S.B.3, Mamin G.V.3, Hairullin R.N.1

1) Interregional Clinical and Diagnostic Centre, Course of Cardiovascular Surgery, Kazan State Medical University of the RF Health Ministry,
2) Chair of Histology of the Kazan State Medical University of the RF Health Ministry,
3) Institute of Physics of the Kazan (Volga Region) Federal University of the Ministry of Education and Science of the Russian Federation, Kazan, Russia

Presented herein is a review of the literature concerning mechanisms of calcification of atherosclerotic plaques (ASP), showing molecular mechanisms of interaction of processes of calcification with the factors inducing instability of ASPs (anti-inflammatory cytokines, neoangiogenesis, increased level of matrix metalloproteinases, etc.), also describing the effect of the value of volume of scope of calcification on stability of ASPs, followed by discussing the problems related to the role of biominerals (hydroxyapatite calcium phosphate) and Mn2+ in calcification of ASPs and their impact upon stability of the plaque.

KEY WORDS: atherosclerotic plaque, calcification, plaque stability, anti-inflammatory cytokines, neoangiogenesis, hydroxyapatite, manganese.

P. 20

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