Journal «Angiology and Vascular Surgery» • 

1998 • VOLUME 4 • №2

SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHI ASSESSMENT OF CAROTID ENDARTERECTOMY EFFECT ON CEREBRAL BLOOD FLOW AND BLOOD VOLUME

U.U. Shvera, V.M. Shipulin, Ju.B. Lishmanov
Laboratoryfor Radionuclide Methods of Examination, The Department for Cardiovascular Surgery of the Scientific-Research Institute of Cardiology of the Siberian Scientific Center of the Siberian Branch of the Russian academy of Medical Sciences,
Tomsk, Russia

The aim of this work is to study a status of regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) in patients with a different stage of carotid stenosis after carotid endarterectomy by a method of single photon emission computed tomography (SPECT). Thirty five patients aged 46-65 years (mean 55 years) were examined. In all the patients 99mTc-hex-amethylpropyleneamineoxime (99mTc-HMPAO, Ceretec, Amersham) and in vivo 99mTo labelled red eryth-rocyte SPECT (99mTc RE) was performed. According to scintigraphic data regional cerebral blood flow (rCBF, ml/min/100g), hypoperfuion value (V, cm3), stroke volume (SV, cm3) interhemi spheric IHrCBF/rCBV ratio was calculated. Carotid endarterectomy results in increase of bilateral cerebral perfusion, on the side of more marked lesion in particular and eliminates interhemispheric rCBF asymmetry. Following carotid endarterectomy SV and V hyperperfusion are regressed. Operative recanalization of carotid arteries results in striking changes in scintigraphic rCBF indices; rCB V values are normalized in patients with an asymptomic course of atherosclerotic carotid artery stenosis and rCBV is subsequently increased in patients with previous acute stroke and neurologic deficit and in patients with "slurred" clinical signs and multiple bilateral internal carotid lesions.

P. 58-70

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