SYSTEMIC ENZYME THERAPY OF LOWER LIMB POSTPHLEBITIC SYNDROME

V.M. Koshkin, A.I. Kirienko, S.G. Leontjev, V.F. Agafonov

Large clinical material (66 patients) and modern diagnostic modalities were used for comparative study of systemic enzyme therapy (Pholenzym, 2 dragees per 3 times per day for 3 months) and conventional combined therapy of lower limb postphlebitic syndrome. Clinical effect of systemic enzyme therapy was more pronounced (84% for systemic enzyme therapy vs 73% for conventional therapy). Better outcome was provided by significant changes in hemostasis and blood rheological parameters, especially by increased blood fibrinolytic activity and inhibited platelet function. These resulted in facilitation of venous outflow from affected extremity and clinical regression of chronic venous insufficiency.

KEY WORDS: systemic enzyme therapy, postphlebitic syndrome, hemostasis, blood rheology, venous outflow.

P. 61-64

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