Journal «Angiology and Vascular Surgery» • 

2014 • VOLUME 20 • №3

Additional methods of diagnosis of unstable atherosclerotic plaques in carotid arteries

Danilova M.A., Baidina T.V., Danilov V.N.

Chair of Neurology of the Therapeutic Department named after Professor V.P. Pervushin, Perm State Medil Academcay named after Academician E.A. Wagner under the Russian Federation Ministry of Public Health, Perm, Russia

The method of enzyme-linked immunosorbent assay (ELISA) was used to study the concentration of interleukins (OL)-6, 10, C-reactive protein (CRP) in blood serum of 61 patients presenting with atherosclerotic lesions of carotid arteries (CA). The obtained findings were compared with the morphological peculiarities of the biopsy materials of the atherosclerotic plaques (ASP) obtained while carrying out carotid endarterectomy (CEA). An increased concentration of IL-6 and CRP in blood serum of patients with unstable ASPs was revealed. It was shown that measuring cytokines and CRP in blood serum may be used as an additional method for diagnosis of unstable nature of ASP in the CAs in order to determine the indications for carotid endarterectomy.

KEY WORDS: carotid endarterectomy, unstable atherosclerotic plaque, C-reactive protein, cytokines.

P. 39

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